MicroRNA-615-5p Regulates Angiogenesis and Tissue Repair by Targeting AKT/eNOS (Protein Kinase B/Endothelial Nitric Oxide Synthase) Signaling in Endothelial Cells.
MouseWounddb/db; C57BL/6MaleIntradermal (wound); intravenous tail vein (hindlimb ischaemia)0.63 mg/kg local intradermal LNA-anti-miR; 1 mg/kg systemic…Wound: 48 h and 24 h before wounding. Hindlimb ischaemia: day before surgery an…
Model: Dorsal full thickness 1 cm punch biopsy skin wound in db/db mice covered with semi-occlusive dressing; unilateral femoral artery ligation hindlimb ischaemia
Local anti-miR-615-5p accelerated wound closure and increased granulation tissue thickness and CD31 angiogenesis in db/db mice, and systemic neutralisation improved perfusion recovery after femoral artery ligation, whereas mimics impaired these responses.
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