Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice.
MouseEndotoxin/LPSBALB/cMalen = Ten mice per group at randomisation across five groups; n=8…Intraperitoneal10 and 20 mg/kg as stated in the Methods; the Figure 5 lege…One hour before intratracheal lipopolysaccharide
Model: Acute lung injury induced by intratracheal instillation of lipopolysaccharide, 20 micrograms at 0.4 micrograms per microlitre
Ganoderic acid A lowered the lung wet-to-dry weight ratio, reduced myeloperoxidase activity and malondialdehyde, raised superoxide dismutase activity, reduced TNF-alpha, IL-1beta and IL-6 in lavage fluid and lessened neutrophil infiltration on histology. These effects were accompanied by suppressio…
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