Influence of fibrin matrices and their released factors on epidermal substitute phenotype and engraftment.
MouseWoundNOD-SCIDSurgical grafting of the cultured epidermal substitute onto the wound bed
Model: Acute full-thickness wound in NOD-SCID mice grafted with cultured epidermal substitutes, as a model for full-thickness burn cover
Human plasma-based fibrin matrix improved keratinocyte migration, proliferation and epidermal substitute organisation compared with fibrin from purified fibrinogen. Both fibrin matrices increased dermal-epidermal junction protein deposition and reduced its degradation, and reduced keratinocyte diff…
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