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PRECLINICAL PUBLICATION · 1987

Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 3105816 ↗1987Reported benefit

Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.

RatSpinal cord injuryContusionInbred strain (not further specified)MaleIntraperitoneal

Model: Acute mechanical (impact) spinal cord injury

Leupeptin and E-64c substantially suppressed neurofilament protein degradation at the site of mechanical insult and at sites of secondary axonal degeneration, and facilitated recovery of motor function.

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.