Anti-inflammatory, antioxidant and antihepatotoxic effects ofagainst d-galactosamine induced hepatotoxicity in rats.
RatChemical/toxinWistar albinon = 36 Wistar albino rats in six groups of sixOral, incorporated into the diet3%, 6% and 9% Spirulina in the dietDietary supplementation given after D-galactosamine administration
Model: Acute hepatotoxicity induced by a single intraperitoneal injection of D-galactosamine at 300 mg/kg body weight, with food withheld for four hours before and after dosing
D-galactosamine caused fatty degeneration, necrosis, apoptosis and perivascular inflammation, raised TNF-alpha, IL-1beta, IL-6 and TBARS, and lowered total protein and antioxidant enzyme activity. Dietary Spirulina gave dose-dependent protection, with 6% and 9% diets restoring near-normal hepatocyt…
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