Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury.
MouseTBIControlled cortical impactOne week of in vivo treatment beginning immediately after injury; in vitro appl…
Model: Controlled cortical impact traumatic brain injury; acute cortical slices studied 3 to 5 weeks after injury
One week of 2-deoxyglucose given immediately after controlled cortical impact prevented development of epileptiform activity, restored excitatory and inhibitory synaptic activity and attenuated loss of parvalbumin-expressing interneurons.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.