Implications of immunotherapy with high-dose glatiramer acetate in acute phase of spinal cord injury in rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemale2 mg/kg high dose compared with 0.5 mg/kg low doseTreatment began after injury, during the acute phase
Model: Experimental spinal cord injury in rats, with sham-operated and injured untreated control groups; the specific injury method is not stated in the abstract
High-dose glatiramer acetate significantly worsened BBB functional recovery at 12 weeks compared with injury control and low-dose groups, accompanied by increased spinal cavity volume and reduced ventral horn motor neurons. Low-dose treatment did not differ significantly from injury control. High d…
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