PRECLINICAL PUBLICATION · 2019

Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization.

Mouse / Chemical/toxin

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Human adipose-derived stem cells coated with lipid-conjugated heparin (Lip-Hep/hADSC)

PMID 31026612 ↗2019Reported benefit

Significantly enhanced recovery of acute liver failure by liver targeted delivery of stem cells via heparin functionalization.

MouseChemical/toxinIntravenous administrationAfter acetaminophen challenge

Model: Acetaminophen (APAP)-induced acute liver failure

Heparin-coated stem cells showed greater hepatic delivery and retention and returned serum transaminases to normal faster than uncoated cells, with reduced inflammatory markers and improved liver histology.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.