Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain.
RatOtherSprague-Dawleymalen = 5 groups of 9 rats each (n = 9 per group); electrophysiolog…intrathecal injection150 or 250 microgram/kg14 days after chronic constriction injury, once mechanical allodynia was establ…
Model: Chronic constriction injury (partial ligation) of the sciatic nerve, neuropathic pain
Chronic constriction injury reduced paw withdrawal threshold to 1.90 +/- 0.31 g versus 15.10 +/- 1.50 g in sham. Intrathecal dehydrocrenatidine dose-dependently reversed mechanical allodynia, with the 250 microgram/kg dose comparable to morphine 50 microgram/kg. DHCT suppressed TTX-S and TTX-R sodi…
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