(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.
RatOtherSprague-Dawleymalen = n = 8 per group for behavioural testingoral (per oris)200 mg/kgadministered at post-operative day 7 after infraorbital nerve transection
Model: Infraorbital nerve transection (IONX), trigeminal neuropathic pain
Infraorbital nerve transection produced facial mechanical hypersensitivity unaffected by vehicle. Bisabolol 200 mg/kg orally significantly reversed the mechanical hypersensitivity for at least 6 h and reversed central sensitisation of medullary dorsal horn nociceptive neurons, restoring activation…
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