-acetyl-seryl-aspartyl-lysyl-proline treatment protects heart against excessive myocardial injury and heart failure in mice.
MouseIschaemia-reperfusionCardiacC57BL/6Jmalen = 73 mice with myocardial infarction in protocol 1 (vehicle n…intraperitoneal continuous infusion by ALZET osmotic minipump1.6 mg/kg per dayminipump implanted 7 days before myocardial infarction in the acute rupture pro…
Model: Myocardial infarction by permanent ligation of the left anterior descending coronary artery
Cardiac rupture at 7 days fell from 60.5% in vehicle-treated to 23.3% in Ac-SDKP-treated mice, with reduced ICAM-1, macrophage infiltration, gelatinolytic activity, p53 and cardiomyocyte apoptosis, and increased capillary density in the infarct border, without change in infarct size. At 5 weeks Ac-…
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