Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury.
MouseTBIControlled cortical impactC57BL/6maleintraparenchymal injection at the lesion site2 x 10^(exponent not recoverable from source encoding) matu…injected immediately before controlled cortical impact
Model: Controlled cortical impact (CCI) contusion traumatic brain injury
Mice given intraparenchymal B cells showed significantly improved post-injury rotarod, Y maze and Morris water maze performance compared with saline or T cell controls, and lesion volume was reduced by 40% at 35 days post-injury, with decreased astrogliosis and microglial activation. Sham groups pe…
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