(-)-Myrtenol accelerates healing of acetic acid-induced gastric ulcers in rats and in human gastric adenocarcinoma cells.
RatChemical/toxinWistarmaleoral administration50 and 100 mg/kg/dayafter ulcer induction, as treatment of the established chronic gastric ulcer
Model: Chronic gastric ulcer induced by serosal injection of 80% acetic acid
Oral (-)-myrtenol at 50 and 100 mg/kg/day for 7 days significantly decreased ulcer area and volume compared with vehicle-treated ulcer controls, with increased gastric mucin, collagen deposition and PCNA-positive cells, altered TNF-alpha, IL-1beta and COX-2 expression and reduced MMP-9 and MMP-2 ac…
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