A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMalen = 31 rats in total; n = 5 per group for ELISA and western blo…Intraperitoneal100 mg/kgFirst dose 30 min after injury
Model: Moderate controlled cortical impact injury to the left parietal cortex (3 mm impactor tip, velocity 3.5 m/s, dwell 0.5 s, depth 2.5 mm) after 4.9 mm craniotomy
JC124 given post-injury abolished injury-induced increases in NLRP3 and ASC, reduced caspase-1 p10, IL-1beta (serum and cortex), TNF-alpha and iNOS, decreased Fluoro-Jade B positive degenerating neurons in cortex, hilus and dentate granule cell layer, reduced OX6 positive cells in peri-lesion corte…
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