A study on the protective effects of CpG oligodeoxynucleotide-induced mucosal immunity against lung injury in a mouse acute respiratory distress syndrome model.
MouseEndotoxin/LPSBALB/cIntranasal and transrectal50 microgram intranasally; 20 microgram transrectallyImmunisation before, or on days 3 and 7 after, establishing the ARDS model
Model: Lipopolysaccharide-induced acute respiratory distress syndrome
CpG ODN given after model induction improved lung pathology, with intranasal 50 microgram producing the least severe injury and the lowest IL-6 and IL-8 levels, followed by rectal 20 microgram. Nasal or rectal CpG ODN given before LPS showed no significant protective effect.
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