Combination of cord blood-derived human hepatic progenitors and hepatogenic factors strongly improves recovery after acute liver injury in mice through modulation of the Wnt/beta-catenin signaling.
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Model: Acute liver injury model in mice
Combining human hepatic progenitors with hepatogenic factors improved engraftment, triggered Wnt/beta-catenin signalling, accelerated the regenerative process and improved rescue of hepatic function compared with hepatogenic factors alone.
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