Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-kB-Mediated Inflammation.
RatEndotoxin/LPSSprague-DawleyMalen = n = 10 rats per groupIn vitro 10 and 20 microM evodiamine; in vivo dose not stat…
Model: Lipopolysaccharide (Escherichia coli 055:B5) induced endotoxaemic acute kidney injury in rats, with parallel LPS-induced cytotoxicity in NRK-52E rat proximal tubular cells (1 microg/ml LPS for 24 h)
Evodiamine ameliorated LPS-induced tubular epithelial oedema, dilation and distortion, reduced the tubular injury score, lowered blood urea nitrogen and creatinine, suppressed serum and kidney TNF-alpha and IL-1beta, inhibited P65 NF-kB expression and reduced ROS production, with protection reverse…
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