PRECLINICAL PUBLICATION · 2019

The protection of New Interacting Motif E shot (NIMoEsh) in mice with collagenase-induced acute stage of intracerebral hemorrhage.

Mouse / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

NIMoEsh (New Interacting Motif E shot), a JNK-inhibitory peptide

PMID 30935978 ↗2019Reported benefit

The protection of New Interacting Motif E shot (NIMoEsh) in mice with collagenase-induced acute stage of intracerebral hemorrhage.

MouseHaemorrhage/shockUnspecifiedC57BL/6Male

Model: Collagenase-induced intracerebral haemorrhage, acute stage

NIMoEsh significantly inhibited JNK activity and reduced brain injury after intracerebral haemorrhage, improving inflammation, white matter damage and neuronal cell death.

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