Mitochondrial DNA-Induced Inflammatory Responses and Lung Injury in Thermal Injury Murine Model: Protective Effect of Cyclosporine-A.
MouseBurnUnspecifiedC57BL/6Malen = 24 mice, 6 per group across four groupsInjection (route not further specified)2.5 mg/kg (low dose) or 25 mg/kg (high dose)15 min before the thermal injury
Model: Full-thickness thermal injury covering 30% of total body surface area, with associated acute lung injury
Cyclosporine-A produced dose-dependent reductions in circulating mitochondrial DNA and inflammatory mediators (p less than .05), mitigated the severity of lung injury and attenuated oxidative stress and release of cytochrome c and mitochondrial DNA in lung tissue.
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