Diverse functions of the thrombopoietin receptor agonist romiplostim rescue individuals exposed to lethal radiation.
MouseRadiationC57BL/6FemaleAfter radiation exposure
Model: Lethal-dose whole-body ionising radiation exposure
Romiplostim administration after lethal-dose irradiation promoted haematopoiesis in multiple organs, reduced organ and cell damage, rapidly increased splenic mesenchymal stem cell number and suppressed several miRNAs involved in radiation-induced leukemogenesis.
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