Antinociceptive and anti-inflammatory effects of cryptotanshinone through PI3K/Akt signaling pathway in a rat model of neuropathic pain.
RatCrushPeripheral-nerve crushSprague-DawleyMaleOralAdministered before surgery, acutely after surgery, or repeatedly after surgery
Model: Chronic constriction injury of the sciatic nerve using four loose ligatures, producing neuropathic pain
Acute post-injury cryptotanshinone, but not pre-surgery treatment, altered paw withdrawal mechanical threshold and thermal withdrawal latency, with a more prominent effect on repeated post-injury dosing, and repeated treatment suppressed the injury-induced rise in IL-6, IL-1beta, TNF-alpha and PI3K…
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