Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses.
MouseIschaemia-reperfusionCardiacC57B6 (C57BL/6)Malen = Short-term arm: 3 groups, n = 10 per group; long-term arm:…Intraperitoneal30 micrograms/kgImmediately after coronary artery ligation surgery
Model: Acute myocardial infarction by permanent ligation of the left anterior descending coronary artery with 10/0 silk suture, 1 mm distal to the left atrial appendage
CHBP reduced histological injury, infarct size and serum CK-MB, increased survival, reduced cardiomyocyte apoptosis, increased ejection fraction and wall thickness while reducing left ventricular end-diastolic volume, lowered pro-inflammatory cytokines and raised IL-4, IL-9 and IL-10 at both 24 hou…
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