4-Aminopyridine as a Single Agent Diagnostic and Treatment for Severe Nerve Crush Injury.
MouseCrushPeripheral-nerve crushSustained early administration after injury
Model: Standard mouse models of traumatic peripheral nerve injury, including severe nerve crush and gap lesions
Sustained early 4-AP administration increased the speed and extent of behavioural recovery more rapidly than could be explained by axonal regeneration, enhanced recovery of nerve conduction velocity, promoted remyelination and increased post-injury axonal area. It also allowed rapid discrimination…
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