Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics.
RatTBIControlled cortical impactSprague-Dawleymalen = 20 rats; 5 per group across 4 groupsintranasal, 5 uL alternately into each naris every 2 min5 ug in 25 uL sterile 0.9% NaCl1 h after injury
Model: Controlled cortical impact, 5 mm craniotomy right hemisphere, 3 mm tip, 2.5 mm depth, 5.0 m/s, 200 ms dwell
Intranasal osteopontin did not improve neurological score, lesion volume, blood-brain barrier or vascular measures at 1 day post-injury but significantly increased activated microglia in the ipsilateral hemisphere and reduced HO-1 expression.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.