Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury.
RatTBIWeight-drop / impact-accelerationSprague-Dawleymalen = Total not stated; 3 to 4 rats per group for individual assa…intracranial microinjection at lesion site, 1.0 mm depth; BMSCs engrafted into injury epicentre at 1 uL/min1.0 uL of 50 mM MDL28170 in 20 percent DMSO; BMSC dose repo…MDL28170 at 30 min post-injury; BMSCs at 24 h post-injury
Model: Weight-drop parietal contusion, 5 mm burr hole right parietal bone, 50 g hammer from 30 cm
MDL28170 preconditioning reduced pro-inflammatory cytokines and graft apoptosis, increased survival of transplanted BMSCs and reduced lesion cavity and neurological deficit compared with BMSCs alone.
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