Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in mice.
MouseFractureFemurBALB/cfemalen = 72 mice across six groups; 12 per control group; 21 deaths…local implantation into the femoral bone defectGentamicin 0.110 mg per cylinder (17.5 mg/mL); vancomycin 0…at primary surgery, together with inoculation of the fracture gap
Model: Implant-associated osteitis: femoral midshaft osteotomy with critical size defect stabilised by a 6-hole titanium locking plate, gap inoculated with Staphylococcus aureus ATCC 29213
Vancomycin-infused CAS/HA significantly reduced colony-forming units and neutrophils at day 42, but no infected group healed the fracture gap and plain CAS/HA in infected mice showed bone destruction and lysis, so use in acute implant-associated infection is not recommended.
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