Nrf2 signaling and inflammation are key events in physical plasma-spurred wound healing.
MouseWoundSKH1-hr hairless immunocompetentfemale and malen = 113 mice; 3 to 9 animals per grouptopical application of the plasma effluent to the wound3 s or 20 s exposure per treatment at a constant 8 mm dista…commenced after wounding
Model: Full-thickness dermal ear wound made by microscissor removal of epidermal and dermal layers, wound area about 3 mm2
Cold plasma accelerated wound closure from day 3 in females and day 6 in males, increased granulation, collagen and angiogenesis and modulated Nrf2 and p53 signalling.
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