The Cardioprotective Effects of Remote Ischemic Conditioning in a Rat Model of Acute Myocardial Infarction.
RatIschaemia-reperfusionCardiacSprague-Dawleymalen = 72 rats, 24 per group across three groupsnon-invasive limb cuff inflation and deflationonce daily after infarction until days 1, 7 and 14
Model: Acute myocardial infarction by ligation of the left anterior descending coronary artery
Remote ischaemic conditioning reduced infarct size by roughly 20 to 27 percent across days 1, 7 and 14, improved haemodynamics and mitochondrial function and reduced cardiomyocyte apoptosis.
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