Effects of Early Altitude Exposure on the Open Abdomen After Laparotomy in Trauma.
MouseHaemorrhage/shockControlledC57BL/6malen = Not stated in abstract; unresuscitated mice had 85 percent…intravenous resuscitationResuscitation to a systolic blood pressure of 50 mmHg (part…after haemorrhage and laparotomy, before simulated evacuation
Model: Controlled haemorrhage to a systolic blood pressure of 25 mmHg with laparotomy, followed by simulated aeromedical evacuation as 1 h hypobaric hypoxia at 8,000 feet
Simulated aeromedical evacuation did not alter survival, acid-base balance or the inflammatory response, although animals with open abdomens showed higher serum IL-10 and TNF-alpha, intestinal IL-6 and IL-10 and pulmonary myeloperoxidase.
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