Early treatment with GLP-1 after severe trauma preserves renal function in obese Zucker rats.
RatFractureUnspecifiedObese ZuckerContinuous intravenous infusion3 micrograms/kg/h, 1.5 mL/kg total volumeFrom 30 min to 5 h after trauma
Model: Bilateral hindlimb soft tissue injury, fibula fracture and homogenised bone component injection (severe extremity trauma)
GLP-1 infusion significantly attenuated early post-traumatic hyperglycaemia, reduced the trauma-induced rise in plasma IL-6 at 1 day, and normalised renal blood flow, glomerular filtration rate and renal oxygen delivery without altering renal oxygen consumption.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.