Protective effect of sophocarpine on lipopolysaccharide-induced acute lung injury in mice.
MouseEndotoxin/LPSBALB/c
Model: Lipopolysaccharide-induced acute lung injury
Sophocarpine attenuated LPS-induced lung histological injury, oedema, BALF protein and inflammatory cell influx, MDA and myeloperoxidase activity, suppressed TNF-alpha, IL-1beta and IL-6, and inhibited IkBalpha and NF-kappaB phosphorylation, MAPK activation and TLR4 expression.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.