Sub-clinical dose of bone morphogenetic protein-2 does not precipitate rampant, sustained inflammatory response in bone wound healing.
MouseWoundC57BL/6 wild-type (Jackson Laboratory)Mixed sexn = 48 mice total, evenly distributed across two surgical group…Local implantation into the calvarial defect325 ng rhBMP-2 per defect, loaded on absorbable collagen sp…At the time of defect creation
Model: 5 mm critical-size calvarial (craniectomy) defect
A sub-clinical rhBMP-2 dose produced only transient modulation of inflammatory markers that largely resolved to control levels by 7 days, with reduced MCP-1, IL-12 and IL-1beta and increased TNF-alpha, IL-13, VEGF and FGF at 3 days. Cellular infiltrate was significantly increased at 3 and 7 days, F…
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