Effects of the ALX/FPR2 receptors of lipoxin A on lung injury induced by fat embolism syndrome in rats.
RatOtherSprague-DawleyMale
Model: Fat embolism syndrome-induced acute lung injury
Fat embolism increased lung injury score, wet-to-dry ratio, BALF protein, leukocytes, neutrophils, myeloperoxidase, TNF-alpha and IL-1beta, alongside raised lipoxin A4 and upregulated ALX/FPR2. BML-111 lowered the inflammatory response, and this benefit was attenuated by the ALX/FPR2 antagonist BOC…
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