Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms.
RatChemical/toxinWistarMale50, 100 and 200 mg/kgPre-treatment before ulcer induction
Model: HCl/ethanol-induced gastric ulcer
The extract reduced the ulcerative lesion index by 83.8, 88.5 and 86.9 per cent at 50, 100 and 200 mg/kg respectively, lowered myeloperoxidase and preserved gastric mucosa. Gastroprotection was reversed by L-NAME and carbenoxolone but not indomethacin, implicating nitric oxide and nonprotein sulfhy…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.