Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells.
MixedIschaemia-reperfusionCardiacIntravenous injectionAfter infarction, following three days of intravenous G-CSF pre-treatment given…
Model: Acute myocardial infarction produced by permanent left anterior descending coronary artery ligation, confirmed by triphenyltetrazolium chloride staining
Intravenous P-CD34 accumulated preferentially in the infarcted heart (capture efficiency about 33.6%), increased endogenous CD34-positive cell recruitment, cardiomyocyte proliferation markers and vascular density, preserved viable myocardium and significantly improved ejection fraction and fraction…
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