Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling.
RatSpinal cord injuryHemisection / partialSprague-DawleyMalen = n = 6 per injury group (SCI only, scaffold, PLLA/bpV(pic),…Local implantation of PLLA/bpV(pic) microspheres into the spinal cord lesion, with or without an acellular spinal cord scaffold20 ng/mL in vitro on rat neural stem cells; in vivo dose no…Implanted at the time of hemisection surgery
Model: Acute spinal cord injury, right-sided hemisections at T9 and T10 with a 2 mm gap created after laminectomy
bpV(pic) significantly improved BBB locomotor scores and preserved anterior horn motor neurons after hemisection, with the acellular scaffold plus bpV(pic) combination giving the largest effect. Treatment raised LC3B and Beclin1 and lowered p62, indicating increased autophagy, and reduced Bax/Bcl-2…
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