PRECLINICAL PUBLICATION · 2019

Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Celastrol loaded in neutrophil membrane-coated PEG-PLGA nanoparticles (NNPs/CLT)

PMID 30753778 ↗2019Reported benefit

Inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis.

RatOtherSprague-DawleyMale

Model: Acute pancreatitis

Neutrophil membrane-coated nanoparticles crossed the blood-pancreas barrier and accumulated selectively in inflamed pancreas. Compared with celastrol solution and uncoated nanoparticles, they significantly reduced serum amylase and pancreatic myeloperoxidase and lowered systemic toxicity of celastr…

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.