The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation.
MouseRadiationC3Hf/Sed//Kam and C57BL/6 (gnotobiotic, defined flora)Malen = 613 male C3H mice across 16 independent experiments and 61…Subcutaneous injection, with a minority of animals dosed orally1 to 75 mg/kg subcutaneously (doses of 1, 2, 5, 25, 50 and…First dose on day 1 after whole-body irradiation
Model: Single whole-body irradiation from a caesium-137 source at about 60 cGy/min, 7.725 Gy in C3H mice and 8.509 Gy in C57BL/6 mice, institutional LD70/30 estimates producing haematopoietic acute radiation syndrome
Active NPS/NPSP mitigators raised 30-day survival from 32.9% in diluent controls to 84.1% and extended median survival time during the acute syndrome from 17 to 18.5 days. Subacute mortality between 30 and 100 days was slightly higher in mitigated animals (about 10% versus one death in controls), b…
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