PRECLINICAL PUBLICATION · 2019

Biohybrids for spinal cord injury repair.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Spinal cord-derived ependymal progenitor cells (epSPC) delivered in a tubular hyaluronic acid conduit containing poly(lactic acid) fibres (biohybrid scaffold)

PMID 30726582 ↗2019Reported benefit

Biohybrids for spinal cord injury repair.

RatSpinal cord injuryComplete transectionSprague-DawleyFemaleSurgical implantation of the cell-loaded conduit at the injury site

Model: Complete spinal cord transection

Biohybrid implantation delivered ependymal progenitor cells efficiently into the transected cord, increased preserved neuronal fibres with a horizontal directional pattern and enhanced GAP43 coexpression, reduced cavity and cyst formation and diminished astrocytic reactivity around the scar.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.