C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury.
MouseChemical/toxinC57BL/6MaleAdeno-associated virus mediated cardiomyocyte-specific overexpression; route of vector administration not statedVector delivered 4 weeks before doxorubicin injection
Model: Acute cardiotoxicity induced by a single intraperitoneal injection of doxorubicin 15 mg/kg
Cardiomyocyte-specific CTRP6 overexpression attenuated doxorubicin-induced cardiac atrophy and apoptosis and improved cardiac function through activation of AKT signalling, with the protection lost when AKT was inhibited.
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