Adjuvant potential of selegiline in treating acute toxicity of aluminium phosphide in rats.
RatChemical/toxinMaleIntraperitoneal injection1 h after aluminium phosphide poisoning
Model: Acute aluminium phosphide poisoning induced by oral gavage, releasing phosphine gas and causing cardiac and gastrointestinal toxicity
Selegiline did not significantly change mortality after aluminium phosphide poisoning, but it reduced cardiac reactive oxygen species and malondialdehyde, increased glutathione, reversed the collapse of mitochondrial membrane potential, improved electrocardiographic parameters and heart rate, and r…
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