Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation.
RatTBIControlled cortical impactLong Evansn = 38 rats in total; n per group not statedIntravenous2 mg/kgFirst injection 80 min after injury, at the onset of blood resuscitation
Model: Cortical contusion impactor traumatic brain injury followed by blood withdrawal to a target mean arterial pressure of 40 mm Hg (haemorrhagic hypotension) and subsequent blood resuscitation
PEG-HCC nearly completely prevented motor dysfunction (p < 0.001 versus diluent), improved Morris water maze performance (p < 0.001 for treatment by time interaction) and reduced lesion size by 61% (p = 0.054).
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.