Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleLocal epicortical implantation of the hydrogel delivery vehicle onto the brain cortexSub-acute phase after stroke
Model: Sub-acute model of cortical stroke in the rat brain with chondroitin sulfate proteoglycan-rich glial scar formation
The N1000G mutation doubled the functional half-life of chondroitinase ABC and PEGylation gave an approximately 10-fold increase in activity relative to unmodified protein after two days. Implantation of the hydrogel containing PEG-N1000G-ChABC-SH3 reduced chondroitin sulfate proteoglycan levels in…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.