Positive Allosteric Modulation of Cholinergic Receptors Improves Spatial Learning after Cortical Contusion Injury in Mice.
MouseTBIControlled cortical impactC57BL/6 (from MeSH indexing)Male (from MeSH indexing)Intraperitoneal5, 10 and 20 mg/kg
Model: Unilateral motorsensory cortical contusion injury, with sham injury controls
BQCA significantly improved spatial recall in the third week with minimal motor effects, modestly increased relative cerebral glucose uptake in motor regions and partially reversed lesion-related changes in hippocampal subregions, with no significant side effects at 20 mg/kg.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.