Menadione (vitamin K3) inhibits hydrogen sulfide and substance P via NF-kappaB pathway in caerulein-induced acute pancreatitis and associated lung injury in mice.
MouseChemical/toxinSwissMaleIntraperitoneal10 mg/kgOne hour after the first caerulein injection
Model: Caerulein-induced acute pancreatitis with associated lung injury, induced by six hourly intraperitoneal injections of caerulein at 50 micrograms/kg
Menadione attenuated the severity of acute pancreatitis and associated lung injury, reducing myeloperoxidase and serum amylase, pro-inflammatory interleukin 1 beta and hydrogen sulfide, and inhibiting substance P signalling and NF-kappaB activation.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.