Hepatoprotective effects of blue honeysuckle on CCl4-induced acute liver damaged mice.
MouseChemical/toxinICRMalen = 60 mice in total, 6 groups of 10Oral gavage200 mg/kg for each extract (20 mg/mL at 10 mL/kg); silymari…Pre-treatment beginning 7 days before carbon tetrachloride, with carbon tetrach…
Model: Carbon tetrachloride-induced acute hepatic damage by a single intraperitoneal injection of 5% (v/v) carbon tetrachloride in olive oil at 10 mL/kg, equating to 0.5 mL/kg carbon tetrachloride
All three blue honeysuckle extracts at 200 mg/kg significantly attenuated carbon tetrachloride-induced liver injury across serum enzymes, lipid peroxidation, antioxidant depletion, necrosis and apoptotic and oxidative immunohistochemical markers, with the enzyme-treated extract the most effective.
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