Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57MaleIntravenous1 h after reperfusion (approximately 2 h after onset of occlusion)
Model: Middle cerebral artery occlusion with a silicon rubber-coated 6-0 suture, 60 min occlusion followed by reperfusion
Resolvin D2-loaded neutrophil nanovesicles accumulated in the injured hemisphere, reduced neutrophil infiltration, myeloperoxidase, ICAM-1 and inflammatory cytokines, lowered infarct volume to 16% compared with 46% after PBS, and improved neurological deficit scores.
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