Simvastatin With PRP Promotes Chondrogenesis of Bone Marrow Stem Cells In Vitro and Wounded Rat Achilles Tendon-Bone Interface Healing In Vivo.
RatWoundSprague-DawleyFemalen = 12 wounded rat Achilles tendon-bone interfacesLocal application to the wounded tendon-bone interface
Model: Surgically wounded Achilles tendon-bone interface
Wounds treated with simvastatin-containing platelet-rich plasma gel healed faster and showed greater safranin O and collagen I and II staining than saline, platelet-rich plasma alone or simvastatin alone.
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