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PRECLINICAL PUBLICATION · 2019

Platelet-rich plasma ameliorates gamma radiation-induced nephrotoxicity via modulating oxidative stress and apoptosis.

Rat / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 30659793 ↗2019Reported benefit

Platelet-rich plasma ameliorates gamma radiation-induced nephrotoxicity via modulating oxidative stress and apoptosis.

RatRadiationMalen = 40 rats distributed in four groupsSubcutaneous0.5 ml/kg body weightProphylactic, given prior to gamma irradiation

Model: Whole body gamma irradiation at a single dose of 8 Gy causing nephrotoxicity

Platelet-rich plasma pre-treatment reduced radiation-induced histological abnormalities and cell injury, ameliorated oxidative stress and appeared to inhibit apoptosis.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.