Effects of altitude changes on mild-to-moderate closed-head injury in rats following acute high-altitude exposure.
RatTBIClosed-head / concussionFollowing injury, with assessment at 6, 12 and 24 h
Model: Mild-to-moderate closed-head injury induced after simulated acute high-altitude exposure at 6,000 m above sea level
Brain injury was significantly reversed following descent to 4,500 m compared with 6,000 m or 3,000 m, and avoiding large-span descent reduced neurological impairment.
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